The Science Advisory Board Newsletter
November 2008

In this Month's Issue:
  • Features:
    • Best Practices Guide: Utilizing Protein Technologies in the Lab
  • Member Spotlights:
    • Genetics and Biochemistry of Seed Lips at CSIC
    • Vaccine Immunology Studies at University of Melbourne
  • Perspectives:
    • Succession Planning in Science: Educating the Next Generation
    • Assassinating Cancer Cells, or Death by Design
    • The Beneficial Effects of Olive Oil
    • Genomic Structural Variation - The End of the Array?
  • Recent Blog Topics
  • Member-Submitted Reviews
Dear ,

November Greetings from The Science Advisory Board!

This month The Science Advisory Board gears up for Neuroscience 2008 in Washington D.C., and we hope to see you there! Staff members will be manning The SAB booth November 16th - November 19th. We look forward to seeing existing members, and we're excited at the opportunity to promote our online community to a new audience. For more details on the Neuroscience 2008 conference, click here.

This month, The SAB recognizes two if its members for their research and recognition in the media (Madhugiri Nageswara-Rao, Ph.D., and Jaya R. Soneji, Ph.D.). We also congratulate Alex Taft on joining The Science Advisory Board team. SAB member count reached the 40,000 mark and weÕre receiving a steady flow of member-submitted content. Enrique Martinez Force, Ph.D., and Brendon Chua, Ph.D., participated in interviews for our Member Spotlights, and Beverly Barton, Ph.D., Tahira Farooqui, Ph.D., and Richard Wintle, Ph.D., contributed new Perspectives. The Science Advisory Board and ChemInsight also presented a Feature article: Best Practices Guide: Utilizing Protein Technologies in the Lab.

We've also included a new collection of interesting forum threads, blog posts, and member-submitted reviews.

Regards,

Kathryn Henwood
Membership Coordinator
The Science Advisory Board
www.scienceboard.net
questions@scienceboard.net

Interesting Forum Threads
In Bio Kits & Reagants: Free Samples in the Lab
In Cell, Tissue & Organ Culture: FACS
sab news
SAB Members in the News! The research of members Madhugiri Nageswara-Rao, Ph.D., and Jaya R. Suneji, Ph.D.
The SAB Welcomes a New Staff Member! Alex Taft joins The Science Advisory Board Team.
Enrique Martinez Force, Ph.D. Brendon Chua, Ph.D.
Enrique Martinez
Force, Ph.D.
Brendon
Chua, Ph.D.
Enrique Force, Ph.D., is Head of the Department of Physiology & Technology of Plant Products at Institute de la Grasa, CSIC (Spanish National Research Council), Spain. Force received his Ph.D. from the University of Seville (1992) and his thesis work focused on, "the biosynthesis of amino acids derived from aspartic acid and the development of threonine and methionine overproducer Saccharomyces cerevisiae mutants." He completed his post-doctoral work in the US; first at the Department of Biochemistry at University of Illinois at Urbana-Champaign and later at the Department of Microbiology and Molecular Biology at Case Western Reserve University. During his post-doc, he worked on the, "characterization of SRP54 protein in Schizosaccharomyces pombe based on site-directed mutagenesis" before joining the Group of Genetics and Biochemistry of Seed Lipids at Instituto de la Grasa, CSIC in 1995.
Brendon Chua, Ph.D., is a postdoctoral research scientist at University of Melbourne, Australia, where he conducts research in the department of Microbiology & Immunology. After completing his Bachelors degree, he worked as a research officer in several clinical trial programs at the Ludwig Institute for Cancer Research and the Peter MacCallum Cancer Centre in Melbourne. Chua was the recipient of a Cooperative Research Centre scholarship and a Major Bartlett scholarship during his Ph.D. studies, and is currently a member of the Cooperative Research Centre for Polymers, "a government supported collaboration to create research synergies between Australian polymer scientists and engineers, and other areas of research and economic strength."
Are you interested in being interviewed for an SAB Member Spotlight? Contact k.henwood@scienceboard.net.
Beverly Barton, Ph.D. - In industry, succession planning is done to insure that knowledge and methods flow smoothly from one generation of management to the next. As scientists, are we doing enough succession planning to insure there will be another generation of working scientists? What are the challenges and solutions we face? In this Perspectives article, I address some of these questions and propose possible solutions.
Beverly Barton, Ph.D. - I am an assassin. Daily I plan the death and destruction of millions of living entities. It's either them or me, or you, for that matter. Them are cancer cells. So I design molecules specific for killing cancer cells, targeted to gain entry in cancer cells. To do this, I take advantage of what distinguishes malignant cells from benign cells, and I constantly search the literature for the latest information on cell targeting strategies.
Tahira Farooqui, Ph.D. - Olive oil is the main component of Mediterranean diet, which is principally a vegetarian diet. Other components of Mediterranean diet are plant-based foods, and wine. Olive oil is obtained from the fruit olive (Olea europaea L.). Its plant belongs to the Oleaceae family. Olive oil has been used in the past as a fuel for traditional oil lamps, but now it is commonly used in cooking, pharmaceuticals, cosmetics and soaps. The composition of olive oil varies by cultivar, region, altitude, time of harvest, and extraction process. It is composed mainly of oleic acid (monounsaturated fatty acid), palmitic acid (saturated fatty acid), and other fatty acids along with traces of squalene, and sterols including phytosterol and tocosterols.
Richard Wintle, Ph.D. - So, is this the end of the genome-wide DNA microarray? Even complete genomic sequencing cannot reliably detect all classes of genomic variation. In particular, direct duplications with perfect or near-perfect homology will likely be mis-assembled as single regions, although these might be revealed by counting read depth of sequence coverage. Other types of events, particularly those in Òhard to assembleÓ regions, might be similarly missed. Paired-end sequencing, whereby sequence reads are derived from each end of a single DNA fragment, can help to overcome this obstacle, by allowing for identification of inversions (when sequence ends map in an unexpected orientation), or insertions and deletions (when they map nearer to, or farther away from, each other than is expected).

Blog Topics
Life Sciences Tools of the Trade: Pedant
Humans in Science: Off Topic
Science: Uncovering & Discovering: Immobilized Enzymes
Feature Article
Best Practices Guide: Utilizing Protein Technologies in the Lab This Best Practices Guide, developed by The Science Advisory Board in conjunction with ChemInsight, features an overview of the tools and technologies used by scientists--specifically, biologists and chemists--who study proteins. By focusing on both biologists and chemists, the reader can benefit from contrasting each discipline's unique approach to conducting protein-based research as well as learn what methodologies appear to be universal. In this guide, insights gleaned from these scientists are integrated to provide a comprehensive picture of how protein-based research is conducted.
Reviews

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