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Employing a Systems Approach to Biology
Jared Carter Roach, M.D., Ph.D.
A Member Since January 1998



As a Senior Scientist at the Institute for Systems Biology (Seattle, Washington), Jared Roach, M.D., Ph.D. is studying intracellular signaling pathways involved in the innate immune response. Specifically, Dr. Roach is deciphering the regulatory networks in macrophages. In addition to his interests in immunology, he also works in the areas of comparative genomics, fine-scale genetic mapping, and systems biology.

Dr. Roach was a founder of the field of strategic genomics. As a graduate student in the Medical Science Training Program at the University of
Washington, he developed the pairwise end-sequencing strategy, also known as whole-genome shotgunning. This strategy is now widely used for genome sequencing, and was used to sequence the genome of the pufferfish by the International Fugu Genome Sequencing Consortium, in which Dr. Roach participates.

Dr. Roach thrives on intellectual challenges that will ultimately benefit humanity and has been interested in science and medicine since he was a small child. At the Institute for Systems Biology, Dr. Roach is now part of a multidisciplinary team of biologists, computer scientists, chemists, engineers, mathematicians, and physicists who seek to understand how complex biological systems function. He especially enjoys integrating hypothesis-driven science with discovery science to paint on a “broader canvas of biology.”

The Institute for Systems Biology is a nonprofit research institute dedicated to the study and application of systems biology. Its ultimate goal is to identify strategies for predicting and preventing diseases such as cancer, AIDS and diabetes. It was founded four years ago and is supported
through numerous government and private foundation grants. Besides supporting cutting-edge research, the institute has a significant educational mission; many of its scientists are involved in educational outreach programs.

On top of his scientific publications, Dr. Roach also recently translated from French and edited, “Les Bases Techniques du Go” (Mastering the Basics of GO) by E. Lim and H. Dicky. His personal Web site is www.strategicgenomics.com . Lest you think that he spends most days indoors thinking, Dr. Roach is also an avid hiker and does a lot of his thinking outdoors too.



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